Intracellular Generation and Accumulation of Amyloid β-Peptide Terminating at Amino Acid 42
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چکیده
منابع مشابه
Soluble γ-Secretase Modulators Selectively Inhibit the Production of the 42-Amino Acid Amyloid β Peptide Variant and Augment the Production of Multiple Carboxy-Truncated Amyloid β Species
Alzheimer's disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), there is a relative increase in the levels of Aβ42 compared to the levels of Aβ40. We previously reported the charact...
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1 Department of Biochemical Sciences, University of Rome“La Sapienza”, Rome 00185, Italy 2 Department of Chemistry, University of Kentucky, Lexington KY 40506-0055 3 Department of Chemistry, Section of Biochemistry, University of Catania, Catania, Italy 4 Center of Membrane Sciences, University of Kentucky, Lexington, KY 40506-0059, USA 5 Sanders-Brown Center on Aging, University of Kentucky, L...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.26.16085